DelveInsight’s Richter’s Syndrome Pipeline Insight, 2021 report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Richter’s Syndrome pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Richter’s Syndrome Overview
Richter’s Syndrome (RS), also known as Richter’s Transformation, is a rare complication of Chronic Lymphocytic Leukaemia (CLL) and/or Small Lymphocytic Lymphoma (SLL). It is characterised by the sudden transformation of the CLL/SLL into a significantly more aggressive form of large cell lymphoma. Richter’s Syndrome occurs in approximately 2-10% of all CLL/SLL patients during the course of their disease.
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List of regions covered in the report
List of companies involved in the report
Richter’s Syndrome Symptoms
The most common symptoms of Richter’s Syndrome arise from a sudden and dramatic increase in the size of lymph nodes (also known as ‘lymphadenopathy’) characterised by usually painless areas of swelling in the neck, axilla, abdomen (most commonly in the spleen, also known as ‘splenomegaly’) or groin. Patients also often experience a dramatic increase in unexplained weight loss, fevers and night sweats (often collectively referred to as ‘B-symptoms’).
Richter’s Syndrome Diagnosis
The definitive or differential diagnosis of Richter’s Syndrome is achieved by an excisional biopsy or CT/ultrasound guided core needle biopsy of an enlarged lymph node that is thought to be indicative of the Richter’s transformation. The current standard first-line treatment for this type of lymphoma is the immuno-chemotherapy using a combination of chemo drugs and a targeted anti-CD 20 monoclonal antibody. Other second-line chemotherapy regimens often used to treat this type of lymphoma (if non-responsive or ‘refractory’ to R-CHOP) include R-ICE, D-HAC, R-DHAP, GIVE, etc.
Richter’s Syndrome Emerging Drugs
Duvelisib: Secura Bio
Duvelisib, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. It is currently in Phase II stage of development for the treatment of Richter’s Syndrome and is being developed by Secura Bio.
Richter’s Syndrome Phases
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Richter’s Syndrome Report Insights
Richter’s Syndrome Report Assessment
Key Questions
Current Scenario and Emerging Therapies:
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